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For people with underlying heart conditions, such as long qt syndrome, taking zofran may increase their already high risk for developing torsade de pointes.

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The development of serotonin syndrome has been reported with 5-HT 3 receptor antagonists aloneMost reports have been associated with concomitant use of serotonergic drugse.gselective serotonin reuptake inhibitorsSSRIsserotonin and norepinephrine reuptake inhibitorsSNRIsmonoamine oxidase inhibitorsmirtazapinefentanyllithiumtramadoland intravenous methylene blueSome of the reported cases were fatalSerotonin syndrome occurring with overdose of ZOFRAN alone has also been reportedThe majority of reports of serotonin syndrome related to 5-HT 3 receptor antagonist use occurred in a post-anesthesia care unit or an infusion center.

In studies and lawsuits filed by mothers and families of injured babiesa number of birth defects are linked to the medicationThese include:

Although ZofranZuplenz and the generic ondansetron are FDA-approved only for use in treating nausea and vomiting after chemotherapy or radiotherapy or after surgerymany doctors prescribe them for off-label usesincluding treatment of morning sickness in expectant mothers.

ElectrocardiogramECGchanges including QT interval prolongation have been seen in patients receiving ondansetronIn additionpostmarketing cases of Torsade de Pointes have been reported in patients using ZOFRANAvoid ZOFRAN in patients with congenital long QT syndromeECG monitoring is recommended in patients with electrolyte abnormalitiese.ghypokalemia or hypomagnesemiacongestive heart failurebradyarrhythmiasor patients taking other medicinal products that lead to QT prolongationsee CLINICAL PHARMACOLOGY

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